Long-lasting Insecticidal Nets to Prevent Visceral Leishmaniasis in the Indian Subcontinent; Methodological Lessons Learned from a Cluster Randomised Controlled Trial
نویسندگان
چکیده
1 ISGlobal, Barcelona Center for International Health Research (CRESIB), Hospital Clínic—Universitat de Barcelona, Barcelona, Spain, 2 Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium, 3 Department of Medicine, B. P. Koirala Institute of Health Sciences, Dharan, Nepal, 4 Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, 5 Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, 6 Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland, 7 Department of Microbiology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal, 8 Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, 9 Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
منابع مشابه
Model-Based Investigations of Different Vector-Related Intervention Strategies to Eliminate Visceral Leishmaniasis on the Indian Subcontinent
The elimination of infectious diseases requires reducing transmission below a certain threshold. The Visceral Leishmaniasis (VL) Elimination Initiative in Southeast Asia aims to reduce the annual VL incidence rate below 1 case per 10,000 inhabitants in endemic areas by 2015 via a combination of case management and vector control. Using a previously developed VL transmission model, we investigat...
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BACKGROUND Visceral leishmaniasis (VL) control in the Indian subcontinent is currently based on case detection and treatment, and on vector control using indoor residual spraying (IRS). The use of long-lasting insecticidal nets (LN) has been postulated as an alternative or complement to IRS. Here we tested the impact of comprehensive distribution of LN on the density of Phlebotomus argentipes i...
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OBJECTIVE To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. DESIGN Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. SETTING Villages in Muzaffarpur district in India and Saptari, Sunsari, and Mora...
متن کاملLong-lasting insecticidal nets fail at household level to reduce abundance of sandfly vector Phlebotomus argentipes in treated houses in Bihar (India).
OBJECTIVE To determine whether the use of long-lasting insecticidal nets (LLINS) at household level are effective in reducing the abundance of Phlebotomus argentipes, vector of anthroponotic visceral leishmaniasis in India, Nepal and Bangladesh. METHODS The impact of two long-lasting nets (Olyset and PermaNet) on indoor sandfly abundance was evaluated in selected houses of three endemic hamle...
متن کاملSerological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial
BACKGROUND Visceral leishmaniasis is the world' second largest vector-borne parasitic killer and a neglected tropical disease, prevalent in poor communities. Long-lasting insecticidal nets (LNs) are a low cost proven vector intervention method for malaria control; however, their effectiveness against visceral leishmaniasis (VL) is unknown. This study quantified the effect of LNs on exposure to ...
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